(Senior) Scientist, Protein Design
2 days ago
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OnsiteFull-timeMid
Summary
Abiologics is seeking a (Senior) Scientist, Protein Design to join their team in Boston, MA. The role involves driving the structure-based design and optimization of synthetic proteins using a proprietary AI-enabled discovery platform.
About the Role
As a Protein Design Scientist, you will design and execute engineering campaigns for SynteinsTM to generate drug candidates. You will create computational design strategies using machine learning tools and collaborate with various teams to optimize designs for function, solubility, and stability. Additionally, you will integrate structural and biophysical data into iterative optimization cycles.
About You
Required:
- PhD in structural biology, biophysics, protein design, or related field.
- 2+ years of hands-on experience in structure-guided protein design.
- Demonstrated proficiency with modern structure prediction and design tools such as RFdiffusion, proteinMPNN, AF2, ESMFold, Boltz, Rosetta or equivalent SOTA tools for in-silico protein engineering.
- Strong understanding of the biophysics of protein folding and interface energetics.
- Demonstrated ability to progress designs from concept to experimental testing.
- Excellent communication skills.
Preferred:
- Experience designing minibinders or proteins.
- Familiarity with non-canonical amino acid design.
- Familiarity with molecular dynamics tools.
- Exposure to high-throughput or automated protein engineering environments.
- Prior work on platform-based or early-stage biotech teams.
Benefits
- Help invent a new class of programmable synthetic proteins.
- Be part of a high-velocity discovery platform with real-time synthesis and screening.
- Collaborate with a deeply interdisciplinary, mission-driven team.
- Redefine the limits of what proteins can do.
Abiologics
A Flagship Pioneering Company
Boston, MA