Functional Genomics Scientist II / Senior Scientist
$120k/y-$180k/y
Light Horse Therapeutics17 hours ago
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OnsiteFull-timeMid
Summary
Light Horse Therapeutics is seeking a Functional Genomics Scientist II / Senior Scientist to join their team in San Diego, CA. The role involves designing, executing, and analyzing CRISPR-based gene editing screens to study oncology and non-oncology targets.
About the Role
As a Functional Genomics Scientist II / Senior Scientist, you will contribute to the design and execution of CRISPR-based mutagenesis screens, validate functional sites, and design chemical campaigns. You will work closely with computational biology, present results at team meetings, and maintain detailed documentation of experiments.
About You
Required:
- PhD in a biological science with 4+ years of experience (industry preferred) with a strong publication record.
- Proficiency in mammalian cell line culture, especially large-scale projects.
- Proficiency in standard molecular biology techniques, including RNA and DNA preparation, analysis of proteins by immunoprecipitation and western blotting, mammalian cell line transfection.
- Track record of being able to work independently, troubleshoot, and create new workflows.
- Excellent technical laboratory skills.
- Excellent written and oral communication skills.
- Attention to details in documenting, executing, and analyzing experiments.
Preferred:
- Experience with large scale functional genomics experiments, including CRISPR-Cas9 mutagenesis screens.
- Experience with lentivirus production, infection, and selection.
- Experience constructing next generation sequencing libraries.
- Experience with state-of-the-art instrumentation including plate readers, flow cytometers, incucyte, epifluorescence microscopes.
- Background in cancer biology.
Benefits
- Competitive total compensation package.
- Supportive team environment.
Light Horse Therapeutics
Light Horse is leading the way in precision genome editing applied to small molecule drug discovery, pioneering approaches to target the root causes of disabling and life-threatening diseases. Its advanced platform identifies cryptic chemically accessible functional domains within targets that play critical roles in disease biology. The high-throughput discovery platform systematically interrogates complex signaling pathways to uncover unique sites of vulnerability. Light Horse interrogates these targets in their native, cellular context to best ensure that discoveries in the lab translate into the clinic. www.lighthorsetx.com
San Diego, CA