Search for Scientist roles in Cambridge, MA, focusing on oligonucleotide synthesis, requiring a PhD or MS with at least 2 years of experience, preferably in biopharma, and with skills in high-throughput automation.

Okay, I've searched for Scientist roles in Cambridge, MA focusing on oligonucleotide synthesis, requiring a PhD or MS with at least 2 years of experience, preferably in the biopharma industry, and involving skills in high-throughput automation. I have found 12 positions for you.

Scientist

Cambridge, MA

Senior

biopharma

high-throughput automation

Can you help me to analyze the job description and company culture?

Sure. Here's the analysis:

Job Analysis:

The primary purpose of the Sr. Scientist/Scientist position at GSK is to spearhead the establishment of pre-clinical capabilities within the oligo synthesis lab, particularly focusing on the synthesis and analysis of oligonucleotides, including ASOs, siRNA, SSO, and RNA editors. This role encompasses a blend of hands-on laboratory work and method development, ensuring that state-of-the-art high-throughput automation workflows are effectively maintained. By interacting closely with analytical and conjugate chemistry teams, the candidate will be instrumental in ensuring that the synthesis processes are not only efficient but also produce high-quality, reproducible results. Challenges may arise in troubleshooting complex chemical issues, adapting methodologies to novel chemistries, and navigating the ever-evolving landscape of oligonucleotide therapeutics. Success in this role will be measured by the candidate's ability to innovate in chemical synthesis processes, contribute to collaborative project goals, and uphold GSK's high standards of quality and integrity in research operations.

Company Analysis:

GSK stands as a pivotal player in the biopharmaceutical sector, driven by a mission to unite science, technology, and talent to combat disease. With specializations in infectious diseases, oncology, and immunology among others, GSK positions itself as both an industry leader and an innovator. The company's culture emphasizes collaboration and inclusivity, fostering an environment where scientists can feel inspired to tackle significant health challenges. For someone in the Sr. Scientist/Scientist role, being a committed team player is essential, as this position will require close collaboration across various scientific teams. Given GSK’s ambitious growth roadmap and commitment to cutting-edge research, this role aligns with broader corporate goals of creating new therapeutic solutions and advancing healthcare outcomes globally. Candidates should be prepared to contribute to high-stakes projects that not only impact company performance but also the health of billions, which underscores the importance of accountability, integrity, and innovative thinking within the organizational culture.

Mock up some interview questions based on the job description.

Absolutely. Here are some mock interview questions that could come up:

Can you describe a time when you faced a complex chemical challenge during a project? How did you approach solving it?
Tell me about a successful collaborative project you worked on. What was your role and contribution?
How have you applied high-throughput automation workflows in your previous roles? Can you provide an example?
What strategies do you employ to ensure the quality and reproducibility of your results?
How would you approach the oligonucleotide synthesis process for a new therapeutic target?
Can you explain your experience with the Mermade 192X synthesizer and how you have used it in your previous work?
Imagine you are overseeing the synthesis of a new ASO. During the process, you notice inconsistencies in your results. What steps would you take to investigate and resolve this issue?
Suppose your team has differing opinions on a method for purification of oligonucleotides. How would you facilitate a productive discussion to reach a consensus?
What draws you to GSK, and how do you see your goals aligning with our mission to advance healthcare?
In what ways do you believe your values and work ethics resonate with GSK's commitment to inclusivity and collaboration?
Could you tell us more about your experience in oligonucleotide conjugation chemistries? How have you leveraged this in past roles?
What questions do you have about GSK’s recent advancements in RNA therapeutics?
Based on your understanding of our therapeutic areas, where do you see the most potential for growth in oligonucleotide therapeutics?
How do you keep abreast of the latest innovations in synthetic chemistry, especially concerning oligonucleotides?
Finally, could you describe your approach to balancing multiple priorities in a fast-paced research environment?

Job Details

Overview Company

Senior Scientist

GSK

2 days ago

Highlight

OnsiteFull-time2+ yearsSenior

Summary

GSK is seeking a Sr. Scientist/Scientist to join their team in Cambridge, MA. The role involves establishing pre-clinical capabilities within GSK’s new oligo synthesis lab, focusing on modalities such as ASOs, siRNA, SSO, and RNA editors.

About the Role

As a Sr. Scientist/Scientist, you will support pre-clinical oligonucleotide high-throughput and mid-scale synthesis capabilities, perform hands-on work, maintain high-throughput automation workflows, and collaborate with various teams to achieve synthetic project goals. You will also maintain standard operating procedures for synthesis, processing, and purification to ensure high-quality, reproducible results.

About You

Required:

PhD with 0+ years, or MS with 2+ or BS with 4+ years’ experience in chemistry or chemical biology or related field.
2+ years' experience in modern synthetic chemistry methods, particularly nucleosides, nucleotides, and oligonucleotide synthesis, purification, and analysis.
Familiarity with Mermade 192X with Poseidon software and ÄKTA Oligosynt synthesizers, Cytiva, ÄKTA Avant and Pure purification systems with Unicorn software, and LC/HRMS, UPHLC, LC/MS analytics.
Proficiency in oligonucleotide synthesis (SPOS), and biological understanding of RNA therapeutics (e.g. ASO, siRNA, SSO, RNA Editors).

Preferred:

MS with 2+ years or above (or PhD +0) in Oligonucleotide synthesis and/or Chemistry and/or related field.
Team-focused with strong initiative and ability to troubleshoot challenges and implement new solutions.
Excellent written and verbal communication skills, attention to detail, organizational skills, and the ability to collaborate effectively with a team.
Experience with oligonucleotide conjugation chemistries is desirable but not required.
Sense of urgency, flexibility, independence and accountability.
Ability to communicate both verbally and in writing with all levels both inside and outside of organization.
Maintain a high level of integrity while balancing multiple priorities and responsibilities.
Must be a committed team player prepared to work in and embrace a team-based culture.

Benefits

Comprehensive benefits program GSK offers US employees.

GSK

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Cambridge, MA