Search for Senior Scientist roles in South San Francisco, specifically in the biopharmaceutical industry, focused on analytical development with experience in mass spectrometry techniques and at least 8 years of industry experience.

Okay, I've searched for Senior Scientist roles in South San Francisco within the biopharmaceutical industry, emphasizing analytical development and requiring at least 8 years of industry experience with expertise in mass spectrometry techniques. I found 47 positions matching your criteria.

Senior Scientist

South San Francisco, CA

Biopharmaceutical

8 years + Experience

Mass Spectrometry

Can you help me to analyze the job description and company culture?

Sure. Here's the analysis:

Job Analysis:

The primary focus of the Senior Scientist I position within the Analytical Development (separations) team at AbbVie is to utilize advanced analytical techniques, particularly mass spectrometry and chromatography, to characterize complex biotherapeutic proteins. This role is fundamentally about developing innovative methodologies that contribute to the understanding and development of AbbVie’s biologic pipeline. The responsibilities involve independent operation of state-of-the-art analytical equipment, adapting conventional methods to contemporary needs, and ensuring high-quality data outputs that inform drug development decisions. Key challenges will include navigating the complexities of protein variants, impurities, and the associated regulatory requirements, necessitating both technical precision and strategic innovation. Success will be reflected through impactful contributions to cross-functional teams, the ability to produce clear analytical results that support drug development, and potentially authoring significant regulatory submissions that aid in the drug approval process.

Company Analysis:

AbbVie is a global biopharmaceutical company committed to delivering innovative medicines to address serious health challenges. With its strong emphasis on research and development, AbbVie positions itself at the cutting edge of the biopharma industry, particularly in complex therapeutic areas, including immunology and oncology. This forward-looking culture suggests an environment rich in collaboration, rapid advancement, and a strong results orientation. The Senior Scientist role fits within a larger team structure but emphasizes individual contributions to collective goals. The company’s commitment to integrity and innovation aligns with the expectations for this role, where a candidate is anticipated not only to deliver results but also to engage in scientific discourse with the broader community. Candidates should be prepared for a fast-paced lab setting that values collaboration and input, ensuring that their work continuously drives the company’s mission forward.

Mock up some interview questions based on the job description.

Absolutely. Here are some mock interview questions that could come up:

Tell me about a time when you faced a significant challenge in protein characterization and how you addressed it.
Describe a specific project where you had to adapt a conventional analytical method to meet new requirements. What was the outcome?
Can you discuss your experience working in cross-functional teams and how you contribute effectively to team dynamics?
What specific techniques have you developed or improved in your previous roles, particularly in mass spectrometry or chromatography?
How do you stay current with advances in analytical techniques, particularly regarding biotherapeutics?
What strategies have you employed to automate routine analyses in your previous roles?
Imagine you detect an unexpected impurity in a biotherapeutic sample. What steps would you take to investigate this anomaly?
If you were tasked with developing a new method for characterizing protein modifications, what preliminary considerations would you take into account?
Why are you interested in working at AbbVie specifically, and how do your professional goals align with the company’s mission?
How would you approach presenting your findings to a cross-functional team that includes non-scientists?
What do you view as the most critical factor in ensuring successful regulatory submissions for biologics?
What questions do you have about the team dynamics within AbbVie’s Analytical Development organization?
Can you describe the aspects of working in a lab environment that you find most appealing and how you leverage that in your work?
What impact do you hope your work will have on AbbVie’s pipeline of biotherapeutics?
Could you explain how your prior experience prepares you to thrive in the fast-paced, collaborative environment at AbbVie?

Job Details

Overview Company

Senior Scientist I, Analytical Development

Lensa

2 months ago

Highlight

OnsiteFull-time8+ yearsSenior

Summary

AbbVie is seeking a Senior Scientist I, Analytical Development (separations) to join their team in South San Francisco, CA. The role involves utilizing advanced mass spectrometry and chromatographic techniques to support the development of complex biotherapeutics.

About the Role

As a Senior Scientist I, you will independently develop and apply cutting-edge techniques, including mass spectrometry, to characterize biotherapeutic proteins and their variants. You will maintain and operate ultrahigh performance liquid chromatography systems and Orbitrap mass spectrometers, adapt new technologies, and automate routine analyses. Collaboration with cross-functional teams to enhance molecule understanding and drive development decisions is essential. You will also author sections of regulatory submissions and engage with the scientific community through publications and presentations.

About You

Required:

MS with 8+ years industry experience, BS with 10+ years industry experience, or PhD in Chemistry, Biochemistry, Analytical Chemistry or related field.
Proven track record of technical achievement in a CMC role.
Solid understanding of protein chemistry and biochemistry related to biotherapeutic protein drug development.
Proficiency in developing and performing HPLC and mass spectrometry for protein characterization and quantification.
Experience with CMC analytical development of monoclonal antibodies and biotherapeutic proteins.
Strong written and verbal communication skills.
Ability to work in a fast-paced, collaborative environment and manage multiple concurrent projects independently.

Preferred:

Familiarity with LCMS methods development (e.g., Peptide Mapping, Native, Top-Down, MAM, PRM, DIA, CDMS).
Experience with common modalities of protein and peptide analyte separation including reverse phase, HILIC, HIC, SEC, affinity capture, CEX, and CZE hyphenated mass spec techniques.
Proficiency with enrichment strategies to differentiate analytes from matrix.
Familiarity with interpretation and verification of mass spectra and use of relevant data analysis software (e.g., Byos/Byonic, Skyline, Proteome Discoverer, Biopharma Finder).

Benefits

401(k)
Vision insurance
Comprehensive benefits package including paid time off, medical/dental/vision insurance.
Eligibility to participate in short-term incentive programs.

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South San Francisco, CA