Senior Staff Bioinformatics Scientist
Confidential Careers12 days ago
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OnsiteFull-timeMid
Summary
Confidential Careers is seeking a Senior Staff Bioinformatics Scientist to join their team in California, United States. The role involves leading the development and improvement of statistical and algorithmic methods for NGS-based variant detection and minimal residual disease (MRD) calling.
About the Role
As a Senior Staff Bioinformatics Scientist, you will be responsible for improving somatic variant-calling algorithms, developing and validating MRD-calling algorithms, designing benchmarking methodologies, leading troubleshooting efforts, implementing algorithms in production-quality code, and collaborating with assay development teams. You will also document analytical methods and communicate findings to stakeholders.
About You
Required:
- Ph.D. in Statistics, Biostatistics, Computer Science, Bioinformatics, Computational Biology, Applied Mathematics, or a related field, with relevant postdoctoral or industry experience.
- Strong foundation in statistical inference and modeling, including uncertainty quantification and decision thresholding.
- Prior experience working with genomics data, including WGS or large-scale NGS datasets.
- Demonstrated software implementation skills in Python and/or a performance-oriented language (e.g., C++, Rust, Java).
- Familiarity with standard genomics data formats and tooling (e.g., FASTQ, BAM/CRAM, VCF).
- Experience working in regulated product development environments (e.g., FDA, IVD).
- Excellent communication and collaboration skills.
Preferred:
- Hands-on experience with cfDNA analysis and/or MRD detection.
- Machine learning experience, particularly in settings involving class imbalance, model evaluation, calibration, and decision optimization.
- Experience collaborating closely with assay development teams on experimental design and data analysis planning.
Confidential Careers
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California, United States